Earlier today, I saw a class by David H Ledbetter at Collège de France who was invited by Jean-Louis Mandel who holds the human genetics chair in that glorious institution.
He talked about his experience of building a large cohort with Whole Exome Sequencing(WES) at Geisinger Health System. He used to work in academia but was recruited by Glenn D Steele another former academic to lead a large genomics program at Geisinger.
What is Geisinger ?
Geisinger is a not for profit organisation that offers health insurance and also runs large hospitals. It covers mainly a rural area of Pennsylvania where the biggest city is Scranton, a city were the tv series The Office was located to symbolize small-town America. However, the headquarters of Geisinger are not even in Scranton, but in Danville with a population of around 5000 habitants. So, not the most glamorous place!
Geisinger seems to have many advantages for the success of a large cohort: